Primary Sex Determination in Drosophila melanogaster does not rely on the Male Specific Lethal (MSL) Complex
نویسنده
چکیده
منابع مشابه
Primary Sex Determination in Drosophila melanogaster Does Not Rely on the Male-Specific Lethal Complex.
It has been proposed that the Male Specific Lethal (MSL) complex is active in Drosophila melanogaster embryos of both sexes prior to the maternal-to-zygotic transition. Elevated gene expression from the two X chromosomes of female embryos is proposed to facilitate the stable establishment of Sex-lethal (Sxl) expression, which determines sex and represses further activity of the MSL complex, lea...
متن کاملPositive selection at the binding sites of the male-specific lethal complex involved in dosage compensation in Drosophila.
In many taxa, males and females differ with respect to their sex chromosomes, and dosage compensation mechanisms have evolved to equalize X-linked gene transcription. In Drosophila, the male-specific lethal (MSL) complex binds to hundreds of sites along the male X chromosome and mediates twofold hypertranscription of the single male X. Two recent studies found evidence for lineage-specific adap...
متن کاملMisregulation of sex-lethal and disruption of male-specific lethal complex localization in Drosophila species hybrids.
A major model system for the study of evolutionary divergence between closely related species has been the unisexual lethality resulting from reciprocal crosses of Drosophila melanogaster and D. simulans. Sex-lethal (Sxl), a critical gene for sex determination, is misregulated in these hybrids. In hybrid males from D. melanogaster mothers, there is an abnormal expression of Sxl and a failure of...
متن کاملSpecies-specific positive selection of the male-specific lethal complex that participates in dosage compensation in Drosophila.
In many taxa, males and females have unequal ratios of sex chromosomes to autosomes, which has resulted in the invention of diverse mechanisms to equilibrate gene expression between the sexes (dosage compensation). Failure to compensate for sex chromosome dosage results in male lethality in Drosophila. In Drosophila, a male-specific lethal (MSL) complex of proteins and noncoding RNAs binds to h...
متن کاملSatellite Repeats Identify X Chromatin for Dosage Compensation in Drosophila melanogaster Males
A common feature of sex chromosomes is coordinated regulation of X-linked genes in one sex. Drosophila melanogaster males have one X chromosome, whereas females have two. The resulting imbalance in gene dosage is corrected by increased expression from the single X chromosome of males, a process known as dosage compensation. In flies, compensation involves recruitment of the male-specific lethal...
متن کامل